Adaptive Regulation of Organ Size Lab
Welcome to the Roselló-Díez lab!
Did you ever wonder about how organs "know" how much they have to grow in order to attain and maintain species-specific body proportions? And how this collective outcome emerges from the combination of individual cell behaviours? So do we! At the Australian Regenerative Medicine Institute (Monash University) our group uses sophisticated genetic models of perturbed limb development to study the local and systemic mechanisms by which growth perturbations are detected and compensated. We use mainly mice, and soon transgenic quails and zebrafish, in which we combine classic morphometric and histological analyses with state-of-the-art imaging and 'omics' techniques in order to obtain a more holistic view of intra- and inter-organ cell communication during organ development and regeneration. While long bones in the limbs are our starting point, we also study how they crosstalk with other connective tissues and with distant organs via the cardiovascular and nervous systems.
Domestic PhD student. Role of negative feedback in the modulation of bone growth
A motivated student is sought for an exciting project to study mechanisms of control of long bone growth by negative feedback. Transgenic mouse and quail models will be used. Contact us for more information. Deadline 31-May-2020